Acute megakaryoblastic leukemia in an infant with a novel t(1;9)(p32;q34).
Cancer Genet Cytogenet
; 122(1): 59-62, 2000 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-11104035
ABSTRACT
We report a case of a 14-month-old girl with acute megakaryoblastic leukemia (AMKL). May-Giemsa staining of the bone marrow cells revealed the proliferation of two distinct types of blasts. One type of blasts had cytoplasmic blebs, and the other showed a lymphoblastic morphology without blebs. Both types of blasts were negative for peroxidase and esterase reactions. Electron microscopic platelet peroxidase (PPO) reaction also revealed the presence of two types of blasts. One had irregular-shaped nuclei and positive PPO reaction in the nuclear envelope and rough endoplasmic reticulum but not in the Golgi apparatus. These types of blasts were considered to be megakaryoblasts. The other had an immature phenotype with round nuclei and positive PPO reaction in the nuclear envelope, rough endoplasmic reticulum, and the Golgi apparatus. The origin of this type of blasts could not be defined by their morphology. Surface marker analysis indicated that most of the leukemic cells expressed platelet markers, gpIIb, gpIIb/IIIa, gpIX, and gpIbalpha. Karyotypic analysis of the bone marrow cells of this unique subset of AMKL demonstrated a novel translocation, t(1;9)(p32;q34).
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Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Plaquetas
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Cromossomos Humanos Par 1
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Cromossomos Humanos Par 9
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Leucemia Megacarioblástica Aguda
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article