A modular synthetic approach toward exhaustively stereodiversified ligand libraries.
Org Lett
; 2(25): 3999-4002, 2000 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-11112627
ABSTRACT
[structure] This report describes a modular approach to the synthesis of stereodiversified natural product-like libraries. Monomers 2 and 3 were coupled in parallel by silyl-tethered olefin metathesis to generate all 16 stereoisomers of cis-enediols 1. All 16 stereoisomers were incorporated into chimerae having flanking peptidic segments. These chimerae exhibited a broad range of hydrophobicities, raising the possibility that stereochemical variation might be used to tune the pharmacologic properties of small molecules.
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Base de dados:
MEDLINE
Assunto principal:
Técnicas de Química Combinatória
/
Ligantes
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article