Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.
Org Lett
; 2(25): 4099-102, 2000 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-11112653
ABSTRACT
[structure] Two general routes to 1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepines are described. Both routes utilize an appropriately functionalized phenethylamino alcohol as the penultimate intermediate the first route makes use of the reductive amination of a benzyl alkyl ketone with alpha-(aminomethyl)benzyl alcohol, while the second route utilizes the addition of a Grignard reagent to the oxazolidine derived from a substitued phenylacetaldehyde and alpha-(methylaminomethyl)benzyl alcohol. In all cases studied, the cis-1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepine was obtained as the major product.
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Base de dados:
MEDLINE
Assunto principal:
Benzazepinas
/
Antagonistas de Dopamina
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article