Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro.
Biochem Biophys Res Commun
; 279(2): 500-4, 2000 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-11118315
ABSTRACT
Bone marrow (BM) cells originally include alpha-fetoprotein (AFP)- and c-Met [a receptor for hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF induced albumin-expressing hepatocyte-like cells. Furthermore, those hepatocyte-like cells expressed cytokeratins 8 and 18, which are typically expressed in normal adult hepatocytes. These findings demonstrate that BM cells include AFP-expressing hepatic progenitor cells that can be differentiated into hepatocytes by HGF in culture, indicating that such cultures are useful resources for cell transplantation therapy for liver diseases.
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Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Diferenciação Celular
/
Fator de Crescimento de Hepatócito
/
Hepatócitos
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article