Sex differences in nevirapine rash.
Clin Infect Dis
; 32(1): 124-9, 2001 01.
Article
em En
| MEDLINE
| ID: mdl-11118391
ABSTRACT
Nevirapine is a nonnucleoside reverse transcriptase inhibitor (NNRTI) that has the most common treatment limiting side effect of rash. Severe rash has been observed in 3% of patients taking nevirapine in clinical trials, 85% of whom were men. In a multicenter, retrospective cohort study of all patients who received nevirapine over a 5-year period, severe rash was noted in 9 of 95 women and 3 of 263 men (risk ratio [RR], 8.31; 95% confidence interval [CI], 2.3-30.0; P=.005). Women were more likely to discontinue nevirapine therapy because of rash (RR, 4.5; 95% CI, 1. 9-10.5; P=.0005). After adjusting for age and baseline CD4 cell count in multivariate analysis, women had a 7-fold increase in risk for severe rash and were 3.5 times more likely to discontinue nevirapine therapy. In women of reproductive age for whom contraception may occur, nevirapine remains the NNRTI of choice. Recognition of sex differences in this severe adverse event will be important in prescribing nevirapine.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Caracteres Sexuais
/
Toxidermias
/
Inibidores da Transcriptase Reversa
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Fármacos Anti-HIV
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Nevirapina
/
Exantema
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article