Retro-nociceptin methylester, a peptide with analgesic and memory-enhancing activity.
Life Sci
; 67(25): 3095-101, 2000 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-11125846
ABSTRACT
Retro-nociceptin methylester (retro-Noc-ME), which has an oppositely directed structure to that of nociceptin, showed weak affinity for nociceptin receptor and antagonized nociceptin-induced inhibition of contraction in a guinea pig ileum (GPI) assay. The peptide induced analgesia after intracerebroventricular (i.c.v.) administration at a dose of 100 nmol per mouse. Analgesia was not blocked by the opioid antagonist naloxone, which suggests that the analgesia is not mediated by opioid receptor. Furthermore, analgesia caused by retro-Noc-ME was not attenuated after repeated administration, that is, there was an absence of tolerance. The peptide improved learning ability after i.c.v. administration in a step-through experiment in mice.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Analgésicos
/
Memória
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article