Multiple primary melanomas.
J Am Acad Dermatol
; 44(1): 22-7, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11148472
ABSTRACT
BACKGROUND:
Patients with clinically diagnosed dysplastic nevi or a family history of melanoma with or without histologically diagnosed dysplastic nevi seem to be at higher risk for the development of multiple melanomas.OBJECTIVE:
Our purpose was to determine which factors increased the risk for the development of subsequent melanomas.METHODS:
This was a retrospective study in 56 patients with 157 melanomas.RESULTS:
Early age at onset (58.9%), clinically diagnosed dysplastic nevi (82.0%), a histologically diagnosed dysplastic nevus (64%), family history of clinically diagnosed dysplastic nevi (70.8%) or melanoma (64.7%) and a histologically diagnosed dysplastic nevus in combination with a family history of melanoma (48%) were found in a high percentage of patients. The mean age at diagnosis was 38.2 years. The mean interval between the first and second melanoma was 34.3 months. Of the second melanomas, 76.8% developed in a different anatomic region from the first melanomas. The mean tumor thickness (Breslow) decreased from 1.11 mm for the first melanomas to 0.90 mm for the second melanomas.CONCLUSION:
The results suggest that genetic factors might be involved in a certain subset of patients in whom melanomas develop early and successively.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Síndrome do Nevo Displásico
/
Melanoma
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article