Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum.
Infect Immun
; 69(2): 1207-11, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11160024
ABSTRACT
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Plasmodium falciparum
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Imunoglobulina G
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Anticorpos Antiprotozoários
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Proteína 1 de Superfície de Merozoito
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article