Early changes in liver perfusion caused by occult metastases in rats: detection with quantitative CT.
Radiology
; 218(2): 556-61, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11161178
ABSTRACT
PURPOSE:
To determine whether computed tomography (CT) can depict liver hemodynamic changes caused by occult hepatic micrometastases in rat. MATERIALS ANDMETHODS:
Liver micrometastases (mean diameter, 500 micrometer +/- 300) were produced in seven BD IX rats by injecting 10(7) DHDK12 PROb colorectal carcinoma cells into the spleen. Macrometastases (mean diameter, 7 mm +/- 3) were produced in four other rats. Five normal rats were studied as controls. CT images were obtained every 300 msec for 30 seconds during the injection of 1 mL per kilogram of body weight of contrast medium. The time-attenuation curves of the aorta, portal vein, and liver were used to calculate liver perfusion with a deconvolution model designed for the dual blood supply.RESULTS:
Micrometastases in an apparently normal liver caused a 34% decrease in portal blood flow and a 25% increase in the mean transit time for the blood to pass through the liver. These findings suggest increased resistance in the sinusoidal capillaries. Similar but greater changes were found in the macrometastases.CONCLUSION:
Occult liver micrometastases in rats generate changes in liver perfusion that can be detected with CT.
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Base de dados:
MEDLINE
Assunto principal:
Tomografia Computadorizada por Raios X
/
Circulação Hepática
/
Neoplasias Hepáticas Experimentais
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article