Polyclonal expansion of CD3(+)/CD4(+)/CD56(+) large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway.
Br J Haematol
; 112(1): 204-7, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11167804
ABSTRACT
Evidence is accumulating regarding CD95/CD95 ligand (Fas/FasL) pathway dysregulation in clonal diseases of the lymphohaemopoietic lineages. According to these observations, it has been proposed that this defect may represent one of the mechanisms of tumour progression. In large granular lymphocyte (LGL) leukaemia, dysregulated apoptosis may represent a key event in the development of malignancy and autoimmunity. This case report describes dysregulation of the Fas/FasL pathway in a chronic polyclonal expansion of CD3(+) LGLs associated with numerous serological immune abnormalities.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Leucemia de Células T
/
Antígenos CD4
/
Complexo CD3
/
Antígeno CD56
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article