p-Hydroxyphenylacetaldehyde, the major product of tyrosine oxidation by the activated myeloperoxidase system can act as an antioxidant in LDL.
FEBS Lett
; 490(1-2): 28-31, 2001 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-11172805
ABSTRACT
The oxidative modification of low density lipoprotein (LDL) may play a significant role in atherogenesis. HOCl generated by the myeloperoxidase/H2O2/Cl- system of activated neutrophils may be operative in vivo making LDL atherogenic. Tyrosine has been found to be oxidized by HOCl to p-hydroxyphenylacetaldehyde (p-HA) capable of modifying phospholipid amino groups in LDL. As an amphiphatic phenolic compound, p-HA may have the potential to act as an antioxidant in the lipid phase of LDL. The present results show that (a) tyrosine exerts a protective effect on LDL modification by HOCl, (b) p-HA could act as antioxidant associated with the lipoprotein preventing cell- and transition metal ion-mediated LDL oxidation and (c) p-HA was able to scavenge free radicals.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Tirosina
/
Peroxidase
/
Lipoproteínas LDL
/
Acetaldeído
/
Antioxidantes
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article