Neoplastic lesions of the human liver in relation to the activity of the cytochrome P-450 dependent monooxygenase system.
Med Sci Monit
; 6(2): 244-8, 2000.
Article
em En
| MEDLINE
| ID: mdl-11208317
ABSTRACT
We studied the activity of Mixed function oxidase (MFO) in human livers affected by cancer. We determined the content of cytochrome P-450 and b5, as well as the activity of their corresponding reductases, according to generally accepted methods. Liver fragments corresponding with a) healthy tissue, b) tissue at the cancer border and, c) cancerous tissue were collected during surgery from patients with liver cancer. We noted that the developing liver cancer decreased the level of cytochrome P-450, even by a magnitude order. The activity of its corresponding reductase was higher in cancerous than in healthy tissues. Cytochrome b5 behaved in an analogous manner, although the decrease in its content was less significant. NADH-cytochrome b5 reductase activity changes were insignificant.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Enzimático do Citocromo P-450
/
Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article