Bepridil inhibition of sodium current in rat hippocampal CA1 neurons.
Zhongguo Yao Li Xue Bao
; 20(9): 819-23, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-11245090
ABSTRACT
AIM:
To study the effects of bepridil on sodium current in rat hippocampal neurons.METHODS:
All experiments were performed on acutely isolated hippocampal pyramidal neurons by means of whole-cell patch-clamp techniques. Recording media contained ion channel blockers to allow the selective activation of voltage-dependent sodium currents.RESULTS:
Bepridil reduced the amplitudes of sodium current in time- and concentration-dependent manners. The half-blocking time was about 10 min in bepridil 10 micromol.L-1, and IC50 was 2.6 (2.3-2.9) micromol.L-1. Bepridil 10 micromol.L-1 shifted the maximal activation of sodium current from -50 mV to -40 mV, and the characteristic voltage of inactivation from -71 mV to -89 mV without changing the slope factor.CONCLUSION:
Bepridil blocked voltage-dependent sodium current of hippocampal CA1 neurons and might have therapeutic actions for ischemia-induced brain damage.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Sódio
/
Bepridil
/
Células Piramidais
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article