Laminin-5 promotes neurite outgrowth from central and peripheral chick embryonic neurons.
Neurosci Lett
; 301(2): 83-6, 2001 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-11248428
ABSTRACT
Laminin-5 (Ln-5) is an essential component of epithelial basal laminae that is also expressed in the developing nervous system. Here we use a convenient, simple and reproducible in vitro fluorescent assay to assess the neurite outgrowth promoting activity of purified Ln-5. Embryonic chick neurons from dorsal root ganglia, ciliary ganglia, and (to a lesser extent) retina extended neurites on Ln-5, but the neurite outgrowth promoting activity was not as great as that of Ln-1 or Ln-2. Neurons from diencephalon, telencephalon, and spinal cord did not respond to Ln-5.
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Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Neuritos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article