Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain.
Brain Res Mol Brain Res
; 88(1-2): 194-8, 2001 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-11295248
ABSTRACT
The precise involvement of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptors in the pleiotropic actions of 5-HT remain incompletely known. To gain insights into their physiological function(s), localization of mRNAs encoding these subtypes was carried out using in situ hybridization on rat brain sections. Localization was heterogeneous. For example, 5-ht(5A) mRNA was widely expressed while 5-ht(5B) mRNA was predominantly expressed in habenula, hippocampus and inferior olive. 5-ht(6) mRNA was abundant in olfactory tubercles and caudate putamen, and highest levels of 5-HT(7) mRNA were observed in multiple thalamic nuclei. These data suggest that these receptors may have distinct functional roles within the serotonergic system.
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Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
Receptores de Serotonina
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article