Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis.
Gut
; 48(5): 605-8, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11302955
ABSTRACT
BACKGROUND AND AIMS:
We previously reported the effect of Helicobacter pylori eradication on hyperammonaemia in patients with liver cirrhosis. However, the role of H pylori as a cause of hyperammonaemia is controversial. We developed an animal model with liver cirrhosis and investigated the effect of H pylori infection on hyperammonaemia. MATERIALS ANDMETHODS:
Five week old male Mongolian gerbils were inoculated orally with broth culture of H pylori. Forty eight gerbils were divided into four groups. Gerbils not inoculated with H pylori were fed a commercial rodent diet (group A) or a choline deficient diet (group C). Gerbils inoculated with H pylori were fed the commercial rodent diet (group B) or the choline deficient diet (group D). Blood ammonia levels of the femoral vein and portal vein were measured 30 weeks later.RESULTS:
All gerbils fed the choline deficient diet developed liver cirrhosis with fatty metamorphosis. The survival rate of group D was significantly lower than that of the other groups. Systemic and portal blood ammonia levels in group D were significantly higher than those in the other groups.CONCLUSIONS:
H pylori infection induces hyperammonaemia in gerbils with liver cirrhosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
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Infecções por Helicobacter
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Hiperamonemia
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Modelos Animais
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Cirrose Hepática Experimental
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article