Post-training injections of catecholaminergic drugs do not modulate fear conditioning in rats and mice.
Neurosci Lett
; 303(2): 123-6, 2001 May 04.
Article
em En
| MEDLINE
| ID: mdl-11311508
ABSTRACT
Studies employing classical fear conditioning (FC) and inhibitory avoidance (IA), two procedurally different aversive tasks, provide different insight into the neuronal mechanism(s) underlying fear learning. We examined whether immediate post-training injections of catecholaminergic drugs modulate memory consolidation in one-trial FC, as has been demonstrated in one-trial IA. Neither epinephrine (0.1, 0.3, 1.0 mg/kg intraperitoneally) nor amphetamine (1.0, 2.0 mg/kg) modulates FC to tone or context, as indicated by freezing in rats. Similarly, epinephrine (0.1, 1.0 mg/kg) and beta-adrenergic antagonists (sotalol and propranolol; 2 mg/kg) also failed to modulate FC in mice. These results indicate that FC is not susceptible to memory modulation by catecholaminergic drugs in the manner described in IA tasks.
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Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
/
Catecolaminas
/
Condicionamento Psicológico
/
Agonistas Adrenérgicos
/
Medo
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article