Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate.
Prostaglandins Other Lipid Mediat
; 64(1-4): 93-106, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11324710
ABSTRACT
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SPP) are lipid mediators released upon platelet activation. The concentration of LPA in serum is estimated at 1-10 microM whereas the concentration in plasma is considerably less. The SPP concentration in serum is 0.5 microM, approximately two-fold higher than the plasma concentration. The lipids are present during tissue injury and promote cellular processes involved in wound repair. LPA and SPP have multiple effects on cells, many of which are pertinent to wound healing and require that the cells interact in some fashion with components of the extracellular matrix. This review focuses on modulation of cell adhesion, cell migration, collagen gel contraction, and fibronectin matrix assembly by LPA and SPP.
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Base de dados:
MEDLINE
Assunto principal:
Esfingosina
/
Lisofosfolipídeos
/
Matriz Extracelular
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article