Maternal serum levels of type I and type III procollagen peptides in pre-eclamptic pregnancy.
J Matern Fetal Med
; 10(1): 40-3, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11332418
ABSTRACT
OBJECTIVE:
To compare maternal serum levels of two markers of collagen synthesis, procollagen I carboxy-terminal peptide (PICP) and procollagen III amino-terminal peptide (PIIINP), in patients with pre-eclampsia and in controls.METHODS:
PICP and PIIINP were measured by radioimmunoassay in maternal serum samples from patients diagnosed with pre-eclampsia at 32 weeks' gestation or later and in controls from the same period of gestation. For PICP, 37 cases and 36 controls were studied; for PIIINP, 12 cases and 19 controls were studied.RESULTS:
Both PICP and PIIINP levels were significantly elevated in patients with pre-eclampsia. PICP and PIIINP levels were, on average, 20% and 80% higher than in controls, respectively.CONCLUSIONS:
These results are in agreement with previous findings that maternal serum levels of PICP and PIIINP are mildly elevated in patients with pre-eclampsia. These markers are unlikely to be useful in the prediction of pre-eclampsia.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Pré-Eclâmpsia
/
Diagnóstico Pré-Natal
/
Pró-Colágeno
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article