Is antigen presentation the primary function of HLA-G?
Microbes Infect
; 3(4): 323-32, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11334750
ABSTRACT
Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
/
Apresentação de Antígeno
/
Antígenos HLA
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article