The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.
J Virol
; 75(12): 5677-83, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11356976
ABSTRACT
The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells. Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the "driving force" for adenoviral late mRNA export.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
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Infecções por Adenovirus Humanos
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Adenovírus Humanos
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Proteínas E4 de Adenovirus
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Proteínas E1B de Adenovirus
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Receptores Citoplasmáticos e Nucleares
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Carioferinas
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article