Synthesis of imidazo[1,2-a]pyridine derivatives as antiviral agents.
Arzneimittelforschung
; 51(4): 304-9, 2001.
Article
em En
| MEDLINE
| ID: mdl-11367871
ABSTRACT
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Piridinas
/
Imidazóis
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article