LC determination of Z-338, novel gastroprokinetic agent in dog plasma by SCX solid phase extraction.
J Pharm Biomed Anal
; 25(3-4): 599-603, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11377040
ABSTRACT
A simple high-performance liquid chromatographic assay with using UV detection (266 nm) was developed to determine a novel gastroprokinetic agent, Z-338 in dog plasma. The extraction procedure using solid-phase extraction with a Isolute SCX column produces extremely clean eluates and a high recovery. Intra- and inter-day variabilities were lower than 5%. The limit of quantitation of the method was 2.5 ng/ml. This assay was applied to the monitoring of Z-338 concentrations in dogs after oral administration. The method also appeared rapid, simple and suitable for therapeutic Z-338 monitoring.
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Benzamidas
/
Fármacos Gastrointestinais
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article