Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
Science
; 292(5522): 1716-8, 2001 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-11387476
ABSTRACT
The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Receptors with mutations in this motif were defective in lysosomal enzyme sorting. The hinge domain of GGA2 bound clathrin, suggesting that GGA2 could be a link between cargo molecules and clathrin-coated vesicle assembly. Thus, GGA2 binding to the CI-MPR is important for lysosomal enzyme targeting.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Proteínas de Transporte
/
Receptor IGF Tipo 2
/
Transporte Proteico
/
Lisossomos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article