The kinetics and mechanisms of the reaction of Mesna with cisplatin, oxiplatin and carboplatin.
Anticancer Res
; 21(2A): 1225-9, 2001.
Article
em En
| MEDLINE
| ID: mdl-11396168
ABSTRACT
BACKGROUND:
Mesna is a sulfohydrate administered as a supportive drug in conjunction with oxazaphosphorines to prevent bladder toxicity from metabolites. When oxazaphosphorines are given simultaneously with platinum drugs, Mesna binds with platinum drugs as well. Previously we showed in cell culture, that Mesna reduces the efficacy of some platinum drugs. Here we elucidate the chemical reaction mechanism. MATERIAL ANDMETHODS:
Cisplatin, Carboplatin and a novel platinum agent Oxiplatin were incubated with Mesna and the rate of disappearance of Mesna was measured, using an oxidation/reduction reaction between MTT and Mesna.RESULTS:
All three platinum agents reacted with Mesna, but the chemical details differed largely. The molar ratios were 31, 21, and 11 for the reactions of Mesna with Oxiplatin, Cisplatin, and Carboplatin, respectively. The speed of the reaction followed a similar pattern, being fastest for Oxiplatin and slowest for Carboplatin.CONCLUSION:
When considering the pharmacokinetics of Mesna and these platinum compounds and their reactivity, it appears unlikely that the reaction of Mesna with Carboplatin will become clinically relevant, while Cisplatin, might react with Mesna in patient serum.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
/
Piridinas
/
Carboplatina
/
Cisplatino
/
Mesna
/
Compostos de Platina
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article