Requirement of ERK activation for visual cortical plasticity.
Science
; 292(5525): 2337-40, 2001 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-11423664
ABSTRACT
Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical administration to monocularly deprived rats prevents the shift in ocular dominance towards the nondeprived eye. These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Potenciação de Longa Duração
/
Proteína Quinase 1 Ativada por Mitógeno
/
Proteínas Quinases Ativadas por Mitógeno
/
Sistema de Sinalização das MAP Quinases
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article