Age-related changes in the mouse outer retina.
Optom Vis Sci
; 78(6): 425-30, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11444632
ABSTRACT
PURPOSE:
To define the physiological and structural changes that may accompany aging in the normal mouse retina.METHODS:
C57BL/6 mice were maintained under cyclic light for either 2, 6, or 12 months. After rod- and cone-mediated corneal electroretinograms (ERG's) were recorded from anesthetized animals, the retinal structure was quantitatively examined. Photoreceptor cell density was measured within 100-microm regions of the central superior and inferior retina. Cone photoreceptor subtypes were identified by immunocytochemistry.RESULTS:
The amplitudes of rod- and cone-mediated ERG's were reduced in older mice, although the overall ERG wave-form did not change appreciably and implicit times were not changed in an age-dependent fashion. In comparison, there was no significant age-related decline in rod or cone photoreceptor density.CONCLUSIONS:
The amplitude of the mouse ERG declines with age. This change does not appear to reflect a change in the structural integrity of the photoreceptor cells. In functional studies of murine models of late-onset retinal disorders, it will be important to take these changes into consideration.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Envelhecimento
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article