Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Neurobiol Dis
; 8(3): 479-91, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11447996
ABSTRACT
There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition. We examined the effects of creatine administration in a transgenic mouse model of HD produced by 82 polyglutamine repeats in a 171 amino acid N-terminal fragment of huntingtin (N171-82Q). Dietary supplementation of 2% creatine significantly improved survival, slowed the development of motor symptoms, and delayed the onset of weight loss. Creatine lessened brain atrophy and the formation of intranuclear inclusions, attenuated reductions in striatal N-acetylaspartate as assessed by NMR spectroscopy, and delayed the development of hyperglycemia. These results are similar to those observed using dietary creatine supplementation in the R6/2 transgenic mouse model of HD and provide further evidence that creatine may exert therapeutic effects in HD.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Creatinina
/
Atividade Motora
/
Neurônios
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article