[Preparation of hepatitis C virus nonstructural region antigens and detection of their relative antibodies].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
; 14(1): 80-4, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-11503033
ABSTRACT
OBJECTIVE:
To investigate the relationship between HCV NS3 and the pathogenesis of HCV and research a method to assess the therapeutic effect of interferon (lEN) in clinic.METHODS:
In a retrospective research, we used HCV-NS3 antigens of different terminals expressed in E. coli which contained the recombinant plasmids involving amino terminal region (N') or carboxyl terminal region (C') of HCV-NS3, to detect the antibodies by Western blot in sera of 63 hepatitis C patients who were treated with IFN.RESULTS:
It proved that antibodies against HCV-NS3 N' and/or HCV NS3 C' terminals in hepatitis C patients may predict the treatment result of IFN, especially in the patients with chronic hepatitis C.CONCLUSIONS:
The detection of antibodies against HCV-NS3 N' and/or C' terminals may be used for evaluation of IFN treatment, especially in chronic hepatitis C ones.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Interferon-alfa
/
Hepatite C
/
Hepacivirus
/
Antígenos da Hepatite C
/
Anticorpos Anti-Hepatite C
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article