Selective expression of FLIP in malignant melanocytic skin lesions.
J Invest Dermatol
; 117(2): 360-4, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11511316
ABSTRACT
FLIP (FLICE Inhibitory Protein) is a recently identified intracellular inhibitor of caspase-8 activation that potently inhibits cell death mediated by all death receptors including Fas and TRAIL. FLIP has recently been shown to favor tumor growth and immune escape in mouse tumor models. We analyzed FLIP expression by immunohistochemistry in a panel of 61 benign and malignant human melanocytic skin lesions. FLIP expression was undetectable in all but one benign melanocytic lesion (31/32, 97%). In contrast, FLIP was strongly expressed in most melanomas (24/29 = 83%). Overexpression of FLIP by transfection in a Fas- and TRAIL-sensitive human melanoma cell line rendered this cell line more resistant to death mediated by both TRAIL and FasL. Selective expression of FLIP by human melanomas may confer in vivo resistance to FasL and TRAIL, thus representing an additional mechanism by which melanoma cells escape immune destruction.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Proteínas de Transporte
/
Regulação Neoplásica da Expressão Gênica
/
Apoptose
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Melanoma
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article