Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1.
J Neurovirol
; 7(2): 149-54, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11517387
ABSTRACT
A number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was available for the dog. When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal dogs it established a latent infection without signs of pathology. Thus, it appears to be suitable as a vector for therapeutic, or marker genes, in this species.
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Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Herpesvirus Humano 1
/
Encefalite por Herpes Simples
/
Vetores Genéticos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article