HIV-1 LTR subtype and perinatal transmission.
Virology
; 287(2): 261-5, 2001 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-11531404
ABSTRACT
Multiple subtypes of HIV-1 have been identified; however, there is little data on the relative transmissibility of viruses belonging to different subtypes. A matched case-control study addressed whether viruses with different long terminal repeat (LTR) subtypes were transmitted equally from mother to infant. The LTR subtype was determined for 45 matched cases and controls who participated in a clinical trial in Tanzania. HIV-1 subtypes A, C, and D and intersubtype recombinant sequences were identified. Exact matched logistic regression analysis showed that viruses containing subtype A or intersubtype recombinant LTRs were 3.2 and 4.8 times more likely to be transmitted from mother to infant than viruses with subtype D LTRs. Viruses containing subtype C LTRs were 6.1 times more likely to be transmitted than those with subtype D LTRs. These differences in transmission were independent of maternal CD4 at enrollment. Thus, it appears that HIV-1 subtype may be associated with differing rates of perinatal transmission in Tanzania.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Repetição Terminal Longa de HIV
/
HIV-1
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article