Inhibitory activities of (-)-epigallocatechin-3-O-gallate against topoisomerases I and II.
Biol Pharm Bull
; 24(9): 1088-90, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11558576
ABSTRACT
The substitution of gallic acid at the 3 position of (-)-epigallocatechin-3-O-gallate (EGCG) increased the inhibition against topoisomerase I from calf thymus gland and topoisomerase II from human placenta, and the substitution of a hydroxyl group at the 3' position increased the inhibition against the topoisomerase I. These results suggested that the 3 and 3' positions of the EGCG molecule play important roles in the process of inhibition of topoisomerases I and II. EGCG showed strong inhibition against topoisomerases I from wheat germ, calf thymus gland and Vero cells, and showed weak or no inhibition against topoisomerases I from carcinoma cells such as A549, HeLa and COLO 201 cells. EGCG differentially inhibited the topoisomerases I from different sources.
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Base de dados:
MEDLINE
Assunto principal:
Catequina
/
Inibidores Enzimáticos
/
Inibidores da Topoisomerase I
/
Inibidores da Topoisomerase II
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article