Structure-activity relationships of apio nucleosides as potential antiviral agents.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 657-60, 2001.
Article
em En
| MEDLINE
| ID: mdl-11563085
ABSTRACT
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Didesoxinucleosídeos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article