Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells.
Apoptosis
; 6(6): 431-9, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11595832
ABSTRACT
Staphylococcus aureus plays an important role in sepsis, pneumonia and wound infections. Here, we demonstrate that infection with several S. aureus strains results in apoptosis of human endothelial cells. S. aureus induced an activation of cellular caspases, the acid sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH2-terminal kinase (JNK). The significance of these findings is indicated by a prevention of S. aureus triggered apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of JNK or caspases, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Apoptose
/
Proteínas Quinases JNK Ativadas por Mitógeno
/
Endotélio
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article