Mechanisms of cognitive set flexibility in Parkinson's disease.
Brain
; 124(Pt 12): 2503-12, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11701603
ABSTRACT
Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitive processes. To circumvent this problem, the present study used the task-set switching procedure in which good performance was independent of rule learning, and in which working memory load was reduced by explicitly cueing the task switches. Our results provide strong evidence for a specific cognitive set shifting deficit in patients with mild Parkinson's disease in a non-learning context, which also cannot be explained by general slowing of cognitive processes. Moreover, the deficit was robust in a small sample of patients at the earliest stages of the disease. Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Cognição
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article