Side effects of influenza vaccination in healthy older people: a randomised single-blind placebo-controlled trial.
Gerontology
; 47(6): 311-4, 2001.
Article
em En
| MEDLINE
| ID: mdl-11721144
ABSTRACT
OBJECTIVES:
To investigate the frequency of side effects following influenza vaccination in healthy participants aged 65-74 years. MATERIALS ANDMETHODS:
A single-blind randomised placebo-controlled trial was performed in general practices in central Liverpool on 729 healthy individuals (341 females and 388 males) aged 65-74 (median age 68.9) years, of whom 552 received influenza vaccine and 177 received placebo. The main outcome measures were analysed from adverse reactions reported by the subjects on a postal questionnaire 3 days after vaccination.RESULTS:
724 (99.3%) questionnaires were returned. 62 (11.3%) participants who received influenza vaccination complained of local symptoms compared with 9 (5.1%) participants who received placebo (difference 6.2%; 95% CI 1.3 to 10.0%; p = 0.02). 192 (35.1%) individuals who received influenza vaccine complained of one or more systemic side effects compared with 75 (42.4%) who received placebo (difference -7.3%; 95% CI -15.6 to 0.9%; p = 0.10).CONCLUSION:
Healthy people belonging to this age group can be reassured that, when compared with placebo, influenza vaccination causes few, if any, systemic side effects and only a low incidence of local side effects.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Vacinação
/
Influenza Humana
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article