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Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats.
Cheng, J T; Liu, I M; Chi, T C; Tzeng, T F; Lu, F H; Chang, C J.
Afiliação
  • Cheng JT; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan. jtcheng@mail.ncku.edu.tw
Diabetes ; 50(12): 2815-21, 2001 Dec.
Article em En | MEDLINE | ID: mdl-11723065
The effect of tramadol on the plasma glucose level of streptozotocin (STZ)-induced diabetic rats was investigated. A dose-dependent lowering of plasma glucose was seen in the fasting STZ-induced diabetic rats 30 min after intravenous injection of tramadol. This effect of tramadol was abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid mu-receptors. However, response to tramadol was not changed in STZ-induced diabetic rats receiving p-chlorophenylalanine at a dose sufficient to deplete endogenous 5-hydroxytrptamine (5-HT). Therefore, mediation of 5-HT in this action of tramadol is ruled out. In isolated soleus muscle, tramadol enhanced the uptake of radioactive glucose in a concentration-dependent manner. The stimulatory effects of tramadol on glycogen synthesis were also seen in hepatocytes isolated from STZ-induced diabetic rats. The blockade of these actions by naloxone and naloxonazine indicated the mediation of opioid mu-receptors. The mRNA and protein levels of the subtype 4 form of glucose transporter in soleus muscle were increased after repeated treatments for 4 days with tramadol in STZ-induced diabetic rats. Moreover, similar repeated treatments with tramadol reversed the elevated mRNA and protein levels of phosphoenolpyruvate carboxykinase in the liver of STZ-induced diabetic rats. These results suggest that activation of opioid mu-receptors by tramadol can increase the utilization of glucose and/or decrease hepatic gluconeogenesis to lower plasma glucose in diabetic rats lacking insulin.
Assuntos
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Base de dados: MEDLINE Assunto principal: Tramadol / Glicemia / Diabetes Mellitus Experimental / Hipoglicemiantes / Proteínas Musculares / Naloxona / Entorpecentes Idioma: En Ano de publicação: 2001 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tramadol / Glicemia / Diabetes Mellitus Experimental / Hipoglicemiantes / Proteínas Musculares / Naloxona / Entorpecentes Idioma: En Ano de publicação: 2001 Tipo de documento: Article