Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe(1))nociceptin(1-13)NH(2).
Brain Res
; 922(1): 118-24, 2001 Dec 13.
Article
em En
| MEDLINE
| ID: mdl-11730709
ABSTRACT
The present study investigated the effect of intraperiaqueductal grey injection of nociceptin/orphanin FQ (N/OFQ) and an antagonist (Nphe(1))nociceptin(1-13)NH(2) on the hindpaw withdrawal response to thermal and mechanical stimulation in rats. N/OFQ (5 nmol) significantly decreased the nociceptive thresholds in both tests and 1, 5 and 10 nmol of (Nphe(1))nociceptin(1-13)NH(2) significantly reversed this effect in a dose dependent way. Our results demonstrate, that N/OFQ has a nociceptive action, possibly through inhibition of PAG neurons. This effect is blocked by the antagonist (Nphe(1))nociceptin(1-13)NH(2) probably via ORL1 receptors in the periaqueductal grey.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Medição da Dor
/
Substância Cinzenta Periaquedutal
/
Peptídeos Opioides
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article