Statin therapy, inflammation and recurrent coronary events in patients following coronary stent implantation.
J Am Coll Cardiol
; 38(7): 2006-12, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11738308
ABSTRACT
OBJECTIVES:
We sought to investigate whether statin therapy affects the association between preprocedural C-reactive protein (CRP) levels and the risk for recurrent coronary events in patients undergoing coronary stent implantation.BACKGROUND:
Low-grade inflammation as detected by elevated CRP levels predicts the risk of recurrent coronary events. The effect of inflammation on coronary risk may be attenuated by statin therapy.METHODS:
We investigated a potential interrelation among statin therapy, serum evidence of inflammation, and the risk for recurrent coronary events in 388 consecutive patients undergoing coronary stent implantation. Patients were grouped according to the median CRP level (0.6 mg/dl) and to the presence of statin therapy.RESULTS:
A primary combined end point event occurred significantly more frequently in patients with elevated CRP levels without statin therapy (RR [relative risk] 2.37, 95% CI [confidence interval] [1.3 to 4.2]). Importantly, in the presence of statin therapy, the RR for recurrent events was significantly reduced in the patients with elevated CRP levels (RR 1.27 [0.7 to 2.1]) to about the same degree as in patients with CRP levels below 0.6 mg/dl and who did not receive statin therapy (RR 1.1 [0.8 to 1.3]).CONCLUSIONS:
Statin therapy significantly attenuates the increased risk for major adverse cardiac events in patients with elevated CRP levels undergoing coronary stent implantation, suggesting that statin therapy interferes with the detrimental effects of inflammation on accelerated atherosclerotic disease progression following coronary stenting.
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Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Angioplastia Coronária com Balão
/
Stents
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Estenose Coronária
/
Reestenose Coronária
/
Anticolesterolemiantes
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article