Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus.
Phytother Res
; 15(8): 718-20, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11746867
ABSTRACT
The antiviral effects of aqueous extracts of Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8-day treatment. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to 128 microg/mL and inhibited the secretion of HBsAg dose dependently. Of the four tested plants, Terminalis chebula exhibited the most prominent anti-HBV activities.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Extratos Vegetais
/
Vírus da Hepatite B
/
Rosácea
/
Hepatite B
/
Fitoterapia
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article