Meiotic silencing by unpaired DNA.
Cell
; 107(7): 905-16, 2001 Dec 28.
Article
em En
| MEDLINE
| ID: mdl-11779466
ABSTRACT
The silencing of gene expression by segments of DNA present in excess of the normal number is called cosuppression in plants and quelling in fungi. We describe a related process, meiotic silencing by unpaired DNA (MSUD). DNA unpaired in meiosis causes silencing of all DNA homologous to it, including genes that are themselves paired. A semidominant Neurospora mutant, Sad-1, fails to perform MSUD. Sad-1 suppresses the sexual phenotypes of many ascus-dominant mutants. MSUD may provide insights into the function of genes necessary for meiosis, including genes for which ablation in vegetative life would be lethal. It may also contribute to reproductive isolation of species within the genus Neurospora. The wild-type allele, sad-1(+), encodes a putative RNA-directed RNA polymerase.
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Base de dados:
MEDLINE
Assunto principal:
DNA Fúngico
/
Proteínas Fúngicas
/
Inativação Gênica
/
Proteínas de Schizosaccharomyces pombe
/
Meiose
/
Neurospora
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article