[Somatostatin analogues for the treatment of gastro-entero-pancreatic neuroendocrine tumours]. / Ruolo degli analoghi della somatostatina nel trattamento dei tumori neuroendocrini gastroenteropancreatici.
Minerva Endocrinol
; 26(4): 225-9, 2001 Dec.
Article
em It
| MEDLINE
| ID: mdl-11782707
ABSTRACT
Somatostatin has represented a significant breakthrough in the treatment of patients with hormone-acting, neuroendocrine gastro-intestinal-pancreatic (NEGEP) neoplasms, even if its short half-life made it impractical in the clinical practice. Over the last recent years new long-acting formulations have been developed from the native peptide. Octreotide, lanreotide and vapeotide are octapeptides with similar biological activity, remarkable stability and longer half-life; an extended-release formulation of octreotide (Octreotide-LAR) and lanreotide (Lanreotide-SR) have been more recently developed by incorporating the peptide in microspheres of a biodegradable polymer. This formulation was conceived to provide patients with the convenience of a once-a-month or twice-a-month injection and to ensure a stable serum concentration between injections and good clinical control of NEGEP tumours symptoms. Nowadays, somatostatin long-acting analogues represent the first treatment option in those patients who doesn't underwent radical surgery; in addition, these substances present no important side effects, ameliorate the prognosis and can exert some degree of tumour growth control.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Somatostatina
/
Tumores Neuroendócrinos
/
Antineoplásicos Hormonais
/
Neoplasias Gastrointestinais
Idioma:
It
Ano de publicação:
2001
Tipo de documento:
Article