Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer.
Ann Thorac Surg
; 72(6): 1868-76, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11789762
ABSTRACT
BACKGROUND:
To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence.METHODS:
We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer.RESULTS:
Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence.CONCLUSIONS:
The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Carcinoma Pulmonar de Células não Pequenas
/
Receptores ErbB
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Neoplasias Pulmonares
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Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article