[High frequency oscillatory ventilation with perfluorocarbon in rabbits with acute lung injury].
Zhonghua Yi Xue Za Zhi
; 81(2): 97-101, 2001 Jan 25.
Article
em Zh
| MEDLINE
| ID: mdl-11798859
ABSTRACT
OBJECTIVE:
To investigate the efficacy of high frequency oscillation with perfluorocarbon (PFC) in rabbits with acute lung injury (ALI).METHODS:
Twenty four rabbits with ALI induced by repeated saline lung lavage were randomly assigned to four groups conventional mechanical ventilation (CMV) group, CMV + PFC group, high frequency oscillation (HFO) group and HFO + PFC group. All rabbits were ventilated for two hours. Blood gases, respiratory system dynamic compliance (Cdyn) and intrapulmonary shunt fraction (Qs/Qt) were measured and calculated at 30, 60, and 120 min during experiment.RESULTS:
Compared with the CMV, statistically improvements were shown in gas exchange, Cdyn and Qs/Qt at 30 min in the CMV + PFC group [PaO(2) 122 mm Hg +/- 15 mm Hg vs. 692 mm Hg +/- 82 mm Hg, PaCO(2) 29.1 mm Hg +/- 2.7 mm Hg vs. 47.1 mm Hg +/- 2.9 mm Hg, Cdyn (1.35 +/- 0.13) vs (0.97 +/- 0.13) ml.cm H(2)O(-1).kg(-1), Qs/Qt 18.1 +/- 1.1 vs.24.5 +/- 2.9] (P < 0.01 approximately 0.05) and remained stable for two hours. Compared with HFO, HFO + PFC improved oxygenation and ventilation more rapidly than HFO did. At 30 min intervals gas exchange and Qs/Qt were significantly improved (PaO(2) 174.9 +/- 18.5 vs 132.3 +/- 19.4, PaCO(2) 26.1 +/- 2.6 vs 34.9 +/- 4.6, Qs/Qt 17.1 +/- 2.4 vs 19.8 +/- 0.9) (P < 0.05)and remained stable to 60 min. The same differences were seen at 60 min.CONCLUSION:
In rabbits with ALI, CMV + PFC could induce a significant improvement in gas exchange and Cdyn. HFO + PFC leads more rapidmy to reach best gas exchange and Cdyn.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ventilação de Alta Frequência
/
Fluorocarbonos
/
Pulmão
Idioma:
Zh
Ano de publicação:
2001
Tipo de documento:
Article