Evaluation of the ELOVL4 gene in patients with age-related macular degeneration.
Ophthalmic Genet
; 22(4): 233-9, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11803489
ABSTRACT
Stargardt-like macular degeneration (STGD(3)) and autosomal dominant macular degeneration (adMD) share phenotypic characters with atrophic age-related macular degeneration (AMD). Mutations in a photoreceptor cell-specific factor involved in the elongation of very long chain fatty acids (ELOVL(4)) were shown to be associated with STGD(3), adMD, and pattern dystrophy. We screened 778 patients with AMD and 551 age-matched controls to define the role of sequence variants in the ELOVL(4) gene in age-related macular degeneration. We detected three sequence variants in the non-coding region and eight variants in the coding region. No statistically significant association was observed between sequence variants in the ELOVL(4) gene and susceptibility to AMD. However, for the detection of modest effects of multiple alleles in a complex disease, the analysis of larger cohorts of patients may be required.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
Proteínas do Olho
/
Degeneração Macular
/
Proteínas de Membrana
/
Mutação
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article