Progesterone receptor status of breast cancer metastases.
J Cancer Res Clin Oncol
; 128(1): 55-60, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11862473
ABSTRACT
PURPOSE:
The usefulness of steroid receptor content in breast cancer metastases for metastatic disease therapy planning was examined in this study.METHODS:
Steroid receptors in primary tumors and corresponding metastases in the same breast cancer patients ( n=23) were determined by five-point DCC assay. We carried out an analysis of the therapeutic response and comparison of the progression-free interval of patients treated with endocrine/chemo-endocrine therapy for metastatic disease according to the positive/negative progesterone receptor status of primary tumors, or of breast cancer metastases. RESULTS ANDCONCLUSIONS:
It seems that the lack of positive progesterone receptors in metastasis (0/8) and conversion from PR+ primary to PR- metastasis (5/8) may be important in describing the non-responder phenotype. We obtained a similar progression-free interval in patients with progesterone receptor-positive/negative primary tumors, but a longer progression-free interval in the patients with progesterone receptor-positive metastases ( n=9) than with negative ones ( n=14), indicating the possibility of using steroid receptor content from metastases for metastatic disease therapy planning.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Receptores de Progesterona
/
Receptores de Estrogênio
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article