Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents.
Farmaco
; 57(2): 135-44, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11902656
ABSTRACT
Four series of ring substituted (E)-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones were prepared by means of modified Claisen-Schmidt condensation of acetylpyrazines with aromatic aldehydes. The structures were confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The compounds were tested for specific biological properties and some derivatives exhibited photosynthesis-inhibiting, antifungal and antimycobacterial properties. The most pronounced effects were observed with compounds substituted with phenolic groups. Ortho-hydroxyl substituted derivatives were more potent than the corresponding para-hydroxyl substituted analogues.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fotossíntese
/
Compostos Heterocíclicos
/
Antifúngicos
/
Antituberculosos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article