The cross-priming APC requires a Rel-dependent signal to induce CTL.
J Immunol
; 168(7): 3283-7, 2002 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-11907083
ABSTRACT
Induction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T Citotóxicos
/
Transdução de Sinais
/
Proteínas Proto-Oncogênicas c-rel
/
Citotoxicidade Imunológica
/
Células Apresentadoras de Antígenos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article