Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 12(7): 993-5, 2002 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-11909701
ABSTRACT
A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.
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Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Norepinefrina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Inibidores da Captação de Neurotransmissores
/
Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article